Caffeine and sulfadiazine interact differently with human serum albumin: A combined fluorescence and molecular docking study
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- 作者：Mullah Muhaiminul Islam ; Vikash K. Sonu ; Pynsakhiat Miki Gashnga ; N. Shaemningwar Moyon ; Sivaprasad Mitra ; smitra@nehu.ac.in" class="auth_mail" title="E-mail the corresponding author ; smitranehu@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human serum albumin ; Caffeine ; Sulfadiazine ; Fluorescence quenching ; Hydrophobic & electrostatic interaction ; Molecular docking
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：152
- 期：Complete
- 页码：23-33
- 全文大小：3024 K
文摘
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Interaction of caffeine and sulfadiazine with HSA was studied.
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Intrinsic Trp fluorescence of HSA is quenched by both the drugs.
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Both CAF and SDZ bind to similar site in HSA.
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Thermodynamics and mode of interaction for the drugs with HSA is different.
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Docking calculation supports the fluorescence spectroscopic results.