Altered signaling in systemic juvenile idiopathic arthritis monocytes
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- 作者：Claudia Macaubasa ; Elizabeth Wonga ; Yujuan Zhanga ; 1 ; Khoa D. Nguyena ; Justin Leea ; Diana Milojevicb ; 1 ; 2 ; Susan Shenoic ; Anne M. Stevensc ; Norman Ilowited ; 3 ; Vivian Sapera ; Tzielan Leea ; Elizabeth D. Mellinsa ; mellins@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Juvenile arthritis ; Monocytes ; IFN signaling ; SOCS1
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：66-74
- 全文大小：1037 K
文摘
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sJIA CD14 monocytes show specific, defective STAT1 phosphorylation downstream of IFNs.
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sJIA monocytes express higher transcript levels of the IFN signaling inhibitor SOCS1.
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Recent changes in medication use in sJIA may alter the IFN hyporesponsiveness.
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Impaired IFN/pSTAT1 signaling consistent with monocyte skewing away from M1 phenotype
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Impaired IFN/pSTAT1 signaling may contribute to disease pathology in sJIA.