Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type
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- 作者：Alice E. Kanea ; b ; c ; alice.kane@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Sarah J. Mitchelld ; sarah.mitchell@nih.gov" class="auth_mail" title="E-mail the corresponding author ; John Macha ; b ; c ; jmach@uni.sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Aniko Huizer-Pajkosa ; b ; aniko.huizerpajkos@health.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author ; Catriona McKenziee ; catriona.mckenzie@sswahs.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author ; Brett Jonesa ; b ; c ; bjones@med.usyd.edu.au" class="auth_mail" title="E-mail the corresponding author ; Victoria Coggerc ; f ; victoria.cogger@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; David G. Le Couteurc ; f ; david.lecouteur@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Rafael de Cabod ; decabora@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Sarah N. Hilmera ; b ; c ; sarah.hilmer@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acetaminophen ; Hepatotoxicity ; Ageing ; Frailty ; Mice ; Liver ; Paracetamol
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：95-106
- 全文大小：1203 K
文摘
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Acute, chronic and sub-acute acetaminophen exposures in old age were modelled in mice.
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There is no change in acetaminophen hepatotoxicity risk in old age or frailty.
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With old age, there is increased NQO1 activity and an increased inflammatory response to acetaminophen.
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In mice, frailty index is negatively correlated with serum protein, albumin and ALP.