Environmental and genetic determinants of childhood depression: The roles of DAT1 and the antenatal environment
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- 作者：Stephanie D&rsquo ; Souzaa ; sdso012@aucklanduni.ac.nz" class="auth_mail" title="E-mail the corresponding author ; John M.D. Thompsonb ; j.thompson@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Rebecca Slykermanb ; RSlykerman@adhb.govt.nz" class="auth_mail" title="E-mail the corresponding author ; Gareth Marlowc ; g.marlow@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Clare Wallc ; c.wall@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Rinki Murphyd ; r.murphy@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Lynnette R. Fergusonc ; l.ferguson@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Edwin A. Mitchellb ; e.mitchell@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Karen E. Waldiea ; k.waldie@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Longitudinal ; Cohort ; SGA ; Mood ; Genotype ; Genetics ; Gene-environment ; Dopamine ; rs1042098 ; SNP
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：197
- 期：Complete
- 页码：151-158
- 全文大小：503 K
文摘
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A SNP from the DAT1 gene interacted with measures of early life stress to influence depressive symptoms in children.
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SGA and a SNP from the dopamine transporter gene DAT1 had an interactive effect on children's depressive symptoms.
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Depression symptoms were greater in children born SGA who are T homozygous for the rs1042098 SNP.
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Adverse antenatal environments leading to low birth weight may exacerbate the effects of certain DAT1 variants on depression.