Molecular characterization of an interleukin-4/13B homolog in grass carp (Ctenopharyngodon idella) and its role in fish against Aeromonas hydrophila infection
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- 作者：Zhi-Jing Yanga ; 1 ; Chang-Hong Lia ; 1 ; Jie Chena ; b ; Hao Zhanga ; Ming-Yun Lia ; Jiong Chena ; b ; jchen1975@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aeromonas hydrophila infection ; Bacterial load ; Grass carp ; Interleukin-4/13B ; Monocyte/macrophage ; M2 polarization ; Sequence analysis ; Survival rate
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：136-147
- 全文大小：3183 K
文摘
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We characterized an IL-4/13B homolog (CiIL-4/13B) from grass carp.
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CiIL-4/13B mRNA expression responded to Aeromonas hydrophila infection.
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rCiIL-4/13B increased fish survival and deceased bacterial load during infection.
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Grass carp MO/MФ treated with rCiIL-4/13B underwent alternative activation.