Reorganization of motor cortex and impairment of motor performance induced by hindlimb unloading are partially reversed by cortical IGF-1 administration
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- 作者：Julien Mysoeta ; j.mysoet@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marie-Hé ; lè ; ne Canua ; marie-helene.canu@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author ; Christophe Gilletb ; christophe.gillet@univ-valenciennes.fr" class="auth_mail" title="E-mail the corresponding author ; Julie Fourneaua ; julie.fourneau@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author ; Cyril Garnierb ; cyril.garnier@univ-valenciennes.fr" class="auth_mail" title="E-mail the corresponding author ; Bruno Bastidea ; bruno.bastide@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author ; Erwan Duponta ; erwan.dupont@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain derived neurotrophic factor ; C ; control ; GABA ; γ-aminobutyric acid ; HU ; hindlimb unloading ; IGF-1 ; insulin-like growth factor 1
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：434-443
- 全文大小：1892 K
文摘
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Sensorimotor restriction affects organization of motor cortex.
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Sensorimotor restriction induces a degradation of motor performance.
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IGF-1 partially reverses cortical shrinkage and decrease in cortical excitability.
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IGF-1 prevents the degradation of spontaneous activity.
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IGF-1 has only a weak effect on challenged and overground locomotion.