Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition
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- 作者：Milan Esnera ; 1 ; Dmitry Graiferb ; 1 ; Matilde E. Lleonartc ; Alex Lyakhovichc ; d ; e ; lyakhovich@gmail.com" class="auth_mail" title="E-mail the corresponding author ; alex.lyakhovich@mail.muni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antibiotics ; Mitochondrial dysfunction ; Mitochondria ; Cancer ; Autophagy ; Mitophagy
- 刊名：Cancer Letters
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：384
- 期：Complete
- 页码：60-69
- 全文大小：2241 K
文摘
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Cells exposed to antibiotics used in routine lab practice result in mitochondrial dysfunction.
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Antibiotics induce ROS-dependent autophagy/mitophagy in both normal and cancer cells.
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Cancer cells are not the perfect target for antibiotics, perhaps due to glycolitic shift.
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Cancer cells repopulation capacity can be reduced by antibiotics and inhibition of autophagy.