Glibenclamide enhances the effects of delayed hypothermia after experimental stroke in rats
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- 作者：Zhou Wua ; Shu-Zhen Zhua ; b ; Ya-Fang Hua ; Yong Gua ; Sheng-Nan Wanga ; Zhen-Zhou Lina ; Zuo-Shan Xiea ; Su-Yue Pana ; pansuyue82@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HT ; hypothermia ; MCAO ; middle cerebral artery occlusion ; SUR1 ; Sulfonylurea receptor 1 ; COX-2 ; cyclooxygenase 2 ; TNF-α ; tumor necrosis factor alpha ; IL-1β ; interleukin-1 beta ; BBB ; blood brain barrier ; CNS ; central nervous system ; SUR1-TRPM4 ; Sulfonylurea receptor 1&ndash ; transient receptor potential 4
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1643
- 期：Complete
- 页码：113-122
- 全文大小：3769 K
文摘
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Glibenclamide enhanced the effects of delayed HT on brain edema and infarct volume.
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Glibenclamide combined with delayed HT improved neurological outcome.
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Glibenclamide combined with delayed HT alleviated BBB damage.
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Glibenclamide combined with delayed HT decreased pro-inflammatory factors.
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Protective effect of HT is determined by the time to cooling initiation.