Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
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- 作者：Qiao Maoa ; Yun-Long Tana ; yltan21@126.com" class="auth_mail" title="E-mail the corresponding author ; Xing-Guang Luob ; Li Tianc ; Zhi-Ren Wanga ; Shu-Ping Tana ; Song Chena ; Gui-Gang Yanga ; Hui-Mei Ana ; Fu-De Yanga ; Xiang-Yang Zhanga ; d
- 关键词：Schizophrenia ; Sensory gating ; Biomarker ; Negative symptom ; COMT
- 刊名：Psychiatry Research
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：242
- 期：Complete
- 页码：271-276
- 全文大小：240 K
文摘
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Compared with controls, schizophrenic patients exhibited P50 sensory gating defects.
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No significant association was found between COMT Val108/158 Met polymorphism and the P50 deficits.
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COMT Val108/158 Met polymorphism may contribute to the negative symptoms of schizophrenia.