Smoothened-independent activation of hedgehog signaling by rearranged during transfection promotes neuroblastoma cell proliferation and tumor growth
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- 作者：Hongfeng Ruana ; b ; c ; 1 ; Huan Luoa ; d ; 1 ; Jirong Wanga ; Xing Jia ; Zhongmiao Zhangd ; Junsong Wue ; Xianning Zhangb ; zhangxianning@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ximei Wua ; xiwu@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：GDNF ; RET ; Hedgehog ; Neuroblastoma
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1860
- 期：9
- 页码：1961-1972
- 全文大小：2142 K
文摘
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GDNF/RET activate Hedgehog/GLI signaling in neuroblastoma cells.
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GDNF/RET/AKT/GSK3β signaling module promotes proteolytic formation of GLI activators.
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RET induces the neuroblastoma cell proliferation and tumor growth through Hedgehog pathway.
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Targeting Hedgehog pathway is a rational approach for the therapy of neuroblastoma.