Computational simulation of static/cyclic cell stimulations to investigate mechanical modulation of an individual mesenchymal stem cell using confocal microscopy
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- 作者：Zakieh Alihemmatia ; Bahman Vahidia ; bahman.vahidi@ut.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Nooshin Haghighipourb ; Mohammad Salehic
- 关键词：Cell specific model ; Finite elements method ; Mechanical modulation ; Stem cell
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：494-504
- 全文大小：5709 K
文摘
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The mesenchymal stem cell was used in the simulation because it is an attractive tissue engineering source for cell therapies.
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The simulation was done using 3- dimensional images through finite elements method.
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Atomic force microscopy was used to determine mechanical properties of stem cells.
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Comparison between effects of static and compressive loadings on cell mechanical modulation is a major objective of the presented work.