Cocaine self-administration differentially affects allosteric A2A-D2 receptor-receptor interactions in the striatum. Relevance for cocaine use disorder
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- 作者：Julia Pintsuka ; b ; juliaofli@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Dasiel O. Borroto-Escuelaa ; c ; Dasiel.BorrotoEscuela@ki.se" class="auth_mail" title="E-mail the corresponding author ; Bartosz Pomiernya ; bartosz.pomierny@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Karolina Wydrad ; wydra@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Magdalena Zaniewskad ; Zaniew@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Malgorzata Filipd ; mal.fil@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Kjell Fuxea ; Kjell.Fuxe@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cocaine self-administration ; Dopamine D2 receptor ; Adenosine A2A receptor ; Allosteric receptor-receptor interactions ; Heteroreceptor complex ; Addiction
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：85-91
- 全文大小：570 K
文摘
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Enhanced antagonistic A2A-D2 interactions in accumbens after cocaine self-administration
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Loss of antagonistic A2A-D2 interactions in dorsal striatum after cocaine self-administration
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Enhancement of D2 recognition in the dorsal striatum contributes to compulsive cocaine seeking.
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Changes in A2A-D2 interactions may be due to differences in heterocomplex composition.
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