Controlled release of diclofenac sodium in glycolipid incorporated micro emulsions

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• 作者：E.P.N. Premarathne^a ; ^{pubudupremarathne@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; D.N. Karunaratne^a ; ^b ; ^{nedrak@pdn.ac.lk" class="auth_mail" title="E-mail the corresponding author} ; A.D.L. Chandani Perera^a ; ^b ; ^{chandanip@pdn.ac.lk" class="auth_mail" title="E-mail the corresponding author} ; ^{chandanip2015@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sorbitan monooleate (PubChem CID ; 9920342) ; Sodium chloride (PubChem CID ; 5234) ; Potassium dihydrogen phosphate (PubChem CID ; 516951) ; Disodium phosphate (PubChem CID ; 24203) ; Potassium chloride (PubChem CID ; 4873) ; Citric acid (PubChem CID ; 311) ; Diclofenac sodium (DS) (PubChem CID ; 5018304)
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：25 September 2016
• 年：2016
• 卷：511
• 期：2
• 页码：890-898
• 全文大小：1186 K

文摘

The effect of the glycolipid, hexadecyl-β-class="smallcaps">d-glucopyranoside, incorporated in microemulsions (ME¹) towards the enhancement of skin absorption and skin permeation of Diclofenac sodium (DS²) was evaluated. A Franz diffusion cell with a piece of pig’s ear epidermis indicated that the optimized ME formulation with glycolipid (0.05 wt%) exhibited significantly higher permeability than the conventional formulations. The releasing profiles of DS from ME formulations exhibited first order release kinetics resembling a diffusion controlled release model for the first 8 h. Incorporating hexadecyl-β-D glucopyranoside in ME formulations shows significant potential as a delivery vehicle in the cosmetics and pharmaceutical industry.