Implications of thermogenic adipose tissues for metabolic health

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• 作者：Christian Schlein ^{c.schlein@uke.de" class="auth_mail" title="E-mail the corresponding author} (PhD student) ; Prof Dr Joerg Heeren ; PhD ; ^{heeren@uke.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：brown adipose tissue ; brown adipocytes ; beige adipocytes ; lipoprotein metabolism ; triglycerides ; BAT regulation
• 刊名：Best Practice Research Clinical Endocrinology Metabolism
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：30
• 期：4
• 页码：487-496
• 全文大小：791 K

文摘

Excess and ectopic fat accumulation in obesity is a major risk factor for developing hyperlipidemia, type 2 diabetes and cardiovascular disease. The activation of brown and/or beige adipocytes is a promising target for the treatment of metabolic disorders as the combustion of excess energy by these thermogenic adipocytes may help losing weight and improving plasma parameters including triglyceride, cholesterol and glucose levels. The regulation of heat production by thermogenic adipose tissues is based on a complex crosstalk between the autonomous nervous system, intracellular and secreted factors. This multifaceted alignment regulates thermogenic demands to environmental circumstances in dependence on available energy resources. This review summarizes the current knowledge how thermogenic tissues can be targeted to combat the burden of diseases with a special focus on lipid metabolism and diseases related to lipoprotein metabolism.