Present status of Accelerator-Based BNCT

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• 作者：Andres Juan Kreiner^a ; ^b ; ^c ; ^{kreiner@tandar.cnea.gov.ar" class="auth_mail" title="E-mail the corresponding author} ; Javier Bergueiro^a ; Daniel Cartelli^a ; ^b ; ^c ; Matias Baldo^a ; Walter Castell^a ; Javier Gomez Asoia^a ; Javier Padulo^a ; Juan Carlos Suá ; rez Sandí ; n^a ; Marcelo Igarzabal^a ; Julian Erhardt^a ; Daniel Mercuri^a ; Alejandro A. Valda^a ; ^b ; Daniel M. Minsky^a ; ^b ; ^c ; Mario E. Debray^a ; ^b ; Hector R. Somacal^a ; ^b ; Marí ; a Eugenia Capoulat^a ; ^b ; ^c ; Marí ; a S. Herrera^a ; ^b ; ^c ; Mariela F. del Grosso^a ; ^c ; Leonardo Gagetti^a ; ^b ; ^c ; Manuel Suarez Anzorena^a ; Nicolas Canepa^a ; Nicolas Real^a ; Marcelo Gun^d ; Herná ; n Tacca^d
• 关键词：Accelerator-Based BNCT ; Different nuclear reactions and accelerator types ; Worldwide activity
• 刊名：Reports of Practical Oncology & Radiotherapy
• 出版年：2016
• 出版时间：March-April 2016
• 年：2016
• 卷：21
• 期：2
• 页码：95-101
• 全文大小：654 K

文摘

This work aims at giving an updated report of the worldwide status of Accelerator-Based BNCT (AB-BNCT).

Background

There is a generalized perception that the availability of accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of BNCT. Accordingly, in recent years a significant effort has started to develop such machines.

Materials and methods

A variety of possible charged-particle induced nuclear reactions and the characteristics of the resulting neutron spectra are discussed along with the worldwide activity in suitable accelerator development.

Results

Endothermic ⁷Li(p,n)⁷Be and ⁹Be(p,n)⁹B and exothermic ⁹Be(d,n)¹⁰B are compared. In addition to having much better thermo-mechanical properties than Li, Be as a target leads to stable products. This is a significant advantage for a hospital-based facility. ⁹Be(p,n)⁹B needs at least 4–5 MeV bombarding energy to have a sufficient yield, while ⁹Be(d,n)¹⁰B can be utilized at about 1.4 MeV, implying the smallest possible accelerator. This reaction operating with a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT. The machines considered are electrostatic single ended or tandem accelerators or radiofrequency quadrupoles plus drift tube Linacs.

Conclusions

⁷Li(p,n)⁷Be provides one of the best solutions for the production of epithermal neutron beams for deep-seated tumors. However, a Li-based target poses significant technological challenges. Hence, Be has been considered as an alternative target, both in combination with (p,n) and (d,n) reactions. ⁹Be(d,n)¹⁰B at 1.4 MeV, with a thin target has been shown to be a realistic option for the treatment of deep-seated lesions.