Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery
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- 作者：Kaiwen Yanga ; Sicheng Wana ; Binbin Chena ; Wenxia Gaoa ; wenxiag@wzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jiuxi Chena ; Miaochang Liua ; Bin Heb ; Huayue Wua ; huayuewu@wzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：β-Cyclodextrin ; Hydrogel ; pH and temperature responsive ; Swelling kinetics ; Drug release
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 January 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：300-306
- 全文大小：1237 K
文摘
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A dual pH and temperature responsive hydrogel was fabricated.
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The swelling behavior of the hydrogel was investigated.
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The release profiles of atorvastatin from the hydrogel were studied.
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The solubility of atorvastatin was improved greatly in the hydrogel.