Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA
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- 作者：Andrew M. Gross1 ; 2 ; Philipp A. Jaeger2 ; Jason F. Kreisberg2 ; Katherine Licon2 ; Kristen L. Jepsen3 ; Mahdieh Khosroheidari3 ; Brenda M. Morsey4 ; Susan Swindells10 ; Hui Shen5 ; Cherie T. Ng9 ; Ken Flagg3 ; 6 ; 11 ; Daniel Chen3 ; 6 ; Kang Zhang3 ; 6 ; 7 ; 8 ; Howard S. Fox4 ; hfox@unmc.edu" class="auth_mail" title="E-mail the corresponding author ; Trey Ideker1 ; 2 ; 3 ; 8 ; tideker@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：62
- 期：2
- 页码：157-168
- 全文大小：2407 K
文摘
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Methylome-wide analysis of HIV chronically infected, cART treated individuals
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HIV+ individuals have an epigenetic age 4.9 years older than healthy controls
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HLA locus is hypomethylated in HIV+ individuals
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HIV methylation aging signature is validated in purified cells