Possible pathogenic engagement of soluble Semaphorin 4D produced by γδT cells in medication-related osteonecrosis of the jaw (MRONJ)
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- 作者：Alexandru Movilaa ; Hani Mawardib ; Kazuaki Nishimurac ; d ; Tomomi Kiyamae ; Kenji Egashiraa ; f ; Jae-Young Kima ; g ; Alessandro Villag ; h ; Hajime Sasakia ; h ; Sook-Bin Woog ; h ; Toshihisa Kawaia ; h ; tkawai@forsyth.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：γδT cells ; Semaphorin 4D ; Medication-related osteonecrosis of jaw ; TNF-α ; Inflammation ; Monoclonal antibody
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：4 November 2016
- 年：2016
- 卷：480
- 期：1
- 页码：42-47
- 全文大小：1215 K
文摘
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γδT, but not αβT, cells prone to migrate into MRONJ site in both humans and mice.
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Upon activation, γδT cells produce more sSema4D than αβT cells, in vitro.
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sSema4D promotes the production of TNF-α from macrophages.
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γδT-KO mice neither develop MRONJ nor produce sSema4D or TNF-α in the lesion.
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Anti-Sema4D mAb suppressed the onset of MRONJ in wild-type mice.