Characterization and pharmacological analysis of two adipokinetic hormone receptor variants of the tsetse fly, Glossina morsitans morsitans
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- 作者：Jelle Caersa ; Jelle.Caers@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Tom Janssena ; 1 ; Tom.Janssen@cistim.be" class="auth_mail" title="E-mail the corresponding author ; Liesbeth Van Rompaya ; Liesbeth.VanRompay@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Valé ; rie Broeckxa ; Valerie.Broeckx@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Jan Van Den Abbeeleb ; c ; jvdabbeele@itg.be" class="auth_mail" title="E-mail the corresponding author ; Gerd Gä ; ded ; gerd.gade@uct.ac.za" class="auth_mail" title="E-mail the corresponding author ; Liliane Schoofsa ; Liliane.Schoofs@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Isabel Beetsa ; Isabel.Beets@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Insect ; Tsetse fly ; Neuropeptide ; Adipokinetic hormone ; G protein-coupled receptor
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：73-84
- 全文大小：2506 K
文摘
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cDNA cloning confirms two tsetse fly akhr splice variants and two AKH encoding genes.
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Both Glomo-AKHRs are dose-dependently activated by two Glomo-AKH peptides in vitro.
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Transcript profiles suggest conserved functions of AKH signaling in tsetse energy metabolism.
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Structure–activity studies reveal pharmacological features of Glomo-AKH neuropeptides.