Identification of aryl hydrocarbon receptor signaling pathways altered in TCDD-treated red seabream embryos by transcriptome analysis
详细信息 查看全文
- 作者：Midori Iidaa ; b ; redgreen@bio.kyutech.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Satoshi Fujiib ; sfujii@bio.kyutech.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masaya Uchidac ; uchida@mizuki-bio.co.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroshi Nakamurac ; ocean@mizuki-bio.co.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshihiro Kagamic ; kagami@mizuki-bio.co.jp" class="auth_mail" title="E-mail the corresponding author ; Tetsuro Agusad ; te-agusa@pu-kumamoto.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masashi Hiranoa ; m-hirano@agr.ehime-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Su-Min Bake ; ladyofkorea@naver.com" class="auth_mail" title="E-mail the corresponding author ; Eun-Young Kime ; eykim08@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Hisato Iwataa ; iwatah@agr.ehime-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：TCDD ; Red seabream ; Microarray ; Transcriptome ; Gene set enrichment analysis
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：177
- 期：Complete
- 页码：156-170
- 全文大小：2020 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
A custom-made microarray with 6000 probes was constructed for the red seabream.
- class="label">•
Differentially expressed genes were identified in TCDD-treated red seabream embryos.
- class="label">•
Pathway and network analyses identified 13 hub genes that mediate TCDD-induced toxicities.
- class="label">•
Toxicities predicted from identified pathways were consistent with previously reported phenotypes.