Magneto acoustic tomography with short pulsed magnetic field for in-vivo imaging of magnetic iron oxide nanoparticles

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• 作者：Leo Mariappan ; PhD^a ; Qi Shao^a ; Chunlan Jiang ; PhD^b ; Kai Yu^a ; Shai Ashkenazi ; PhD^a ; John C. Bischof ; PhD^a ; ^b ; Bin He ; PhD^a ; ^c ; ^{binhe@umn.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Magneto motive force ; Magnetic nano particle ; In-vivo ; Magneto acoustic tomography ; Ultrasound
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：12
• 期：3
• 页码：689-699
• 全文大小：1411 K

文摘

Nanoparticles are widely used as contrast and therapeutic agents. As such, imaging modalities that can accurately estimate their distribution in-vivo are actively sought. We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on live, nude mice with IONP injected into LNCaP tumors grown subcutaneously within the hind limb of the mice. Our experimental results indicate that the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore, MAT could become an imaging modality for high resolution reconstruction of MNP distribution in the body.

From the Clinical Editor

Many magnetic nanoparticles (MNPs) have been used as contrast agents in magnetic resonance imaging. In this study, the authors investigated the use of ultrasound to detect the presence of MNPs by magneto acoustic tomography. In-vivo experiments confirmed the imaging quality of this new approach, which hopefully would provide an alternative method for accurate tumor detection.