Transforming growth factor-尾, MAPK and Wnt signaling interactions in colorectal cancer
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- 作者：Harish R. Cherukua ; Abidali Mohamedalib ; David I. Cantora ; Sock Hwee Tanc ; Edouard C. Niced ; Mark S. Bakera ; mark.baker@mq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transforming growth factor-尾 ; Colorectal cancer ; TGF尾 crosstalk ; MAPK pathways ; Wnt
- 刊名：EuPA Open Proteomics
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：8
- 期：Complete
- 页码：104-115
- 全文大小：909 K
文摘
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TGF尾 promotes tumor growth during cancer through Smad-independent mechanisms.
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TGF尾 does not have single signaling signature.
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TGF尾 and its receptors participate in crosstalk with various MAPK pathways.
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Wnt and TGF尾 together regulate genes that are involved in the EMT.
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Genetic alterations to TGF尾 signalling further add to the complexity of TGF尾 crosstalk.