Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring
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- 作者：Shelly A. Buffington1 ; 2 ; Gonzalo Viana Di Prisco1 ; 2 ; Thomas A. Auchtung3 ; 4 ; Nadim J. Ajami3 ; 4 ; Joseph F. Petrosino3 ; 4 ; Mauro Costa-Mattioli1 ; 2 ; costamat@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：neurodevelopmental disorders ; autism ; dysbiosis ; high-fat diet (HFD) ; ventral tegmental area (VTA) ; long-term potentiation (LTP) ; probiotic
- 刊名：Cell
- 出版年：2016
- 出版时间：16 June 2016
- 年：2016
- 卷：165
- 期：7
- 页码：1762-1775
- 全文大小：3277 K
文摘
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Maternal high-fat diet (MHFD) induces behavioral alterations in offspring
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MHFD causes alterations in gut microbial ecology in offspring
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MHFD offspring show deficient synaptic plasticity in the VTA and oxytocin production
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L. reuteri treatment restores oxytocin levels, VTA plasticity and social behaviors