Hypothalamic neuropeptide signaling in alcohol addiction
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- 作者：Jessica R. Barson jbarson@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah F. Leibowitz ; leibow@mail.rockefeller.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACh ; acetylcholine ; ARC ; arcuate nucleus of the hypothalamus ; CRF ; corticotropin-releasing factor ; DA ; dopamine ; DMN ; dorsomedial nucleus ; DOR ; delta opioid receptor ; DYN ; dynorphin ; ENK ; enkephalin ; GAL ; galanin ; KOR ; kappa opioid receptor ; LH ; lateral hypothalamus ; MC ; melanocortin ; MC3R ; melanocortin 3 receptor ; MC4R ; melanocortin 4 receptor ; MCH ; melanin-concentrating hormone ; MSH ; melanocyte-stimulating hormone ; NAc ; nucleus accumbens ; NPY ; neuropeptide Y ; OX ; orexin/hypocretin ; OX1R ; orexi
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 February 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：321-329
- 全文大小：495 K
文摘
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Certain orexigenic hypothalamic neuropeptides promote alcohol drinking and reward.
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These same neuropeptides participate in a positive feedback relationship to alcohol.
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Anorexigenic hypothalamic neuropeptides inhibit alcohol drinking and reward.
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These neuropeptides act in a negative feedback relationship to alcohol.
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Hypothalamic neuropeptides regulating food intake also control alcohol intake.