Disinfection by-products exposure and intra-uterine growth restriction: Do genetic polymorphisms of CYP2E1or deletion of GSTM1 or GSTT1 modify the association?
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- 作者：Patrick Levalloisa ; patrick.levallois@msp.ulaval.ca" class="auth_mail" title="E-mail the corresponding author ; Yves Giguè ; reb ; yves.giguere@fmed.ulaval.ca" class="auth_mail" title="E-mail the corresponding author ; Moliè ; re Nguile-Makaoc ; moliere.nguile@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Manuel Rodriguezd ; manuel.rodriguez@esad.ulaval.ca" class="auth_mail" title="E-mail the corresponding author ; Cé ; line Campagnae ; celine.campagna@inspq.qc.ca" class="auth_mail" title="E-mail the corresponding author ; Robert Tardiff ; robert.tardif@umontreal.ca" class="auth_mail" title="E-mail the corresponding author ; Alexandre Bureaug ; alexandre.bureau@msp.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：DBPs ; Intra-uterine-growth-restriction ; Gene polymorphisms ; CYP2E1 ; GSTM1 ; GSTT1
- 刊名：Environment International
- 出版年：2016
- 出版时间：July-August 2016
- 年：2016
- 卷：92-93
- 期：Complete
- 页码：220-231
- 全文大小：400 K
文摘
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Fetal growth restriction was associated with disinfection by-products intra-uterine exposure.
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Modification of the association for child carriers of C alleles of the CYP2E1 rs3813867 polymorphism was not replicated.
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Modification of the association for mothers with deletion of the GSTT1 was not replicated.
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No statistically significant gene-environment interaction was found after correction for multiple testing.