Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
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- 作者：Marie-Theres Weil1 ; Wiebke Mö ; bius3 ; 4 ; Anne Winkler5 ; Torben Ruhwedel3 ; 4 ; Claudia Wrzos5 ; Elisa Romanelli6 ; Jeffrey L. Bennett7 ; Lukas Enz8 ; Norbert Goebels9 ; Klaus-Armin Nave3 ; 4 ; Martin Kerschensteiner6 ; 11 ; Nicole Schaeren-Wiemers8 ; Christine Stadelmann5 ; Mikael Simons1 ; 2 ; 10 ; 11 ; msimons@gwdg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：16
- 期：2
- 页码：314-322
- 全文大小：4256 K
文摘
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Characterization of myelin sheath pathology close its native state
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Vesiculation of inner sheath layers is a common feature of myelin pathology
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Loss of MBP function triggers myelin vesiculation
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Elevation of intracellular Ca2+ triggers MBP phase transition