Epigenetic regulation of dorsal raphe GABAB1a associated with isolation-induced abnormal responses to social stimulation in mice
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- 作者：Ryota Arakia ; r-araki@pharm.setsunan.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yosuke Hirakia ; Shoji Nishidaa ; Nobuyuki Kuramotob ; Kinzo Matsumotoc ; Takeshi Yabea ; yabe@pharm.setsunan.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Isolation rearing ; DNA methylation ; Histone acetylation ; GABAB receptor ; Dorsal raphe nucleus ; Social stimulation
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：1-12
- 全文大小：1120 K
文摘
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Isolation-reared mice have GABAB1a upregulation in the DRN.
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Dorsal raphe GABAB receptors regulate responses to social stimulation.
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Isolation-reared mice have DNA hypomethylation in the dorsal raphe GABAB1a promoter.
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Isolation-reared mice have histone H3 hyperacetylation in the dorsal raphe GABAB1a promoter.