Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy
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- 作者：Timothy A. Simeone ; Ph.D ; timothysimeone@creighton.edu" class="auth_mail" title="E-mail the corresponding author ; Stephanie A. Matthews ; M.S ; Kaeli K. Samson ; M.S ; Kristina A. Simeone ; Ph.D
- 关键词：Epilepsy ; Peroxisome proliferator activated receptor ; Ketogenic diet ; Nutrition ; Seizure ; Kv1.1 ; Kcna1 ; PPARgamma2
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：54-64
- 全文大小：1366 K
文摘
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The ketogenic diet increases PPARγ2 in the brains of epileptic mice.
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Pharmacologic inhibition of PPARγ2 prevents ketogenic diet anti-seizure effects.
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Genetic loss of PPARγ2 prevents ketogenic diet anti-seizure effects.
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PPARγ agonism increases PPARγ2 and attenuates spontaneous recurrent seizures in epileptic mice.