The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y
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- 作者：Yun Maa ; b ; luckymayun@163.com" class="auth_mail" title="E-mail the corresponding author ; Shuai Tiana ; tianshuaismile@163.com" class="auth_mail" title="E-mail the corresponding author ; Shuya Hea ; b ; heshuya8502@163.com" class="auth_mail" title="E-mail the corresponding author ; Qiong Chenc ; chenqiong12@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Zongbao Wangb ; wangzb65@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Xiao Xiaoa ; Liang Fua ; Xiaoyong Leib ; 1622214323@qq.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：mRNA ; messenger ribonucleic acid ; miRNA ; micro ribonucleic acid ; TNF-α ; tumor necrosis factor-alpha ; SH-SY5Y ; cells SH-SY5Y neuroblastoma cells ; Ago2 ; Argonaute 2 ; USP32 ; ubiquitin specific peptidase 32 ; RAB18 ; member RAS oncogene family ; Dusp6 ; dual specificity phosphatase 6 ; Cdkn1a ; cyclin-dependent kinase inhibitor 1A ; Bcl-2 ; B-cell lymphoma-2 ; FMRP ; fragile X mental retardation protein ; FXR1P ; fragile X-related 1 protein ; FXR2P ; fragile X-related 2 protein ; 3&prime ; UTR ; 3&prime ; untranslated
- 刊名：Gene
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：588
- 期：1
- 页码：62-68
- 全文大小：888 K
文摘
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We firstly found and confirmed that miR-19b-3p could act on FXR1.
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3′ UTR and reversely be regulated by FXR1.
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Both FMR1 and FXR1 are important genes for the process of FXS.
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FXR1, USP32, RAB18 and Dusp6 are target genes of miR-19b-3p.
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We, for the first time, demonstrated that miR-19b-3p was involved in the proliferation, apoptosis and cycle of SH-SY5Y cells.