Effects of Pluronic F127-PEG multi-gel-core on the release profile and pharmacodynamics of Exenatide loaded in PLGA microspheres
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- 作者：Puxiu Wang wpx609612@sina.com" class="auth_mail" title="E-mail the corresponding author ; Qian Wang wangqmoyu@163.com" class="auth_mail" title="E-mail the corresponding author ; Tianyang Ren 267261211@qq.com" class="auth_mail" title="E-mail the corresponding author ; Haoyu Gong 976724171@qq.com" class="auth_mail" title="E-mail the corresponding author ; Jingxin Gou 837412837@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yu Zhang 55211933@qq.com" class="auth_mail" title="E-mail the corresponding author ; Cuifang Cai caicuifang@163.com" class="auth_mail" title="E-mail the corresponding author ; Xing Tang ; tangpharm@126.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：360-367
- 全文大小：2042 K
文摘
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Pluronic—PEG multi-gel-core was used to prepare PLGA microsphere and store drug.
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Exenatide was located at the hydrophilic domain of F127-PEG.
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The biological activity of drug was protected by multi-gel-core structure.
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The drug release is controlled by both PLGA and multi-gel-core.