Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress
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- 作者：Jun Lua ; lujun512@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Jian Chena ; cjcchengjian@126.com" class="auth_mail" title="E-mail the corresponding author ; Nianjun Xub ; xunianjun@nbu.edu.dn" class="auth_mail" title="E-mail the corresponding author ; Jun Wua ; junwu302@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yani Kanga ; kangyani@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Tingting Shena ; talentanan@126.com" class="auth_mail" title="E-mail the corresponding author ; Hualei Konga ; khl0798@163.com" class="auth_mail" title="E-mail the corresponding author ; Chao Mac ; marshallshutcm@163.com" class="auth_mail" title="E-mail the corresponding author ; Ming Chenga ; mingcheng@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhifeng Shaoa ; zs9q@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; Ling Xuc ; d ; xulq67@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Xiaodong Zhaoa ; c ; xiaodongzhao@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DDP ; cisplatin ; JFK ; Jinfukang ; TCM ; Traditional Chinese Medicine ; RNA ; seq RNA sequencing ; CCK8 ; cell counting kit 8 ; PI ; propidium iodine ; RT-qPCR ; quantitative real-time PCR ; DAVID ; database for annotation visualization and integrated discovery ; GO ; gene ontology ; KEGG ; Kyoto encyclopedia of genes and genomes ; REVIGO ; Reduce Visualize Gene Ontology ; CAMs ; cell adhesion molecular
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：258
- 期：Complete
- 页码：227-236
- 全文大小：2461 K
文摘
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Cisplatin and Jinfukang, combined treatment at low concentrations, enhances cell apoptosis of human lung cancer cells.
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Transcriptome profiling analysis revealed that combination of Cisplatin and Jinfukang regulates genes involved in apoptosis-related signaling pathways.
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Activation of AIFM2 plays an important role in pro-apoptosis of human lung cancer cells.