NOX1 mediates chemoresistance via HIF1α/MDR1 pathway in gallbladder cancer
详细信息 查看全文
- 作者：Ming Zhan1 ; Hui Wang1 ; Tao Chen ; Wei Chen ; Linhua Yang ; Min He ; Sunwang Xu ; Jian Wang ; dr_wangjian@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gallbladder cancer ; NOX1 ; HIF1α ; MDR1 ; Chemoresistance ; Cisplatin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：79-85
- 全文大小：1849 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
NOX1 is upregulated in gallbladder cancer and associated with cisplatin-sensitivity.
- class="label">•
Enforced NOX1 expression resulted in promotion of cisplatin-resistance in SGC-996.
- class="label">•
Inhibition of NOX1 promotes the cisplatin-sensitivity of GBC-SD in vitro and in vivo.
- class="label">•
NOX1-mediated chemoresistance is related with the ROS/HIF-1α/MDR1 pathway.