Cross-talk between EPAS-1/HIF-2α and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell
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- 作者：Jiuda Zhaoa ; b ; 1 ; Zhenzhong Baic ; 1 ; Fan Fengd ; Erlin Songe ; f ; Feng Dua ; Junhui Zhaob ; Guoshuang Shenb ; Faxiang Jib ; Guoyuan Lib ; Xinfu Mab ; Xingyi Hangg ; Binghe Xua ; xubinghe2002@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：EPAS-1 ; Endothelial PAS domain-containing protein 1 ; PXR ; Pregnane X Receptor (PXR) ; MDR ; multi-drugs resistance ; CYP3A4 ; cytochromes P450 3A4 ; HIF-2α ; hypoxia-inducible transcription factors ; ARNT ; aryl hydrocarbon receptor nuclear translocator ; HRE ; hypoxia response element ; Sp1 ; Specificity protein 1 ; RXR ; retinoid X receptor ; SRC-1 ; steroid receptor co-activator 1 ; HRP ; horseradish peroxidase ; PVDF ; poly-vinylidene fluoride ; ChIP ; Chromatin immunoprecipitation ; AIB1 ; amplified in breast canc
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：73-88
- 全文大小：6424 K
文摘
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A protein–protein interaction between EPAS-1/HIF-2 αand PXR was identified.
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EPAS-1 enhanced the activity of PXR signaling pathway via several mechanisms.
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EPAS-1 attenuated the effect of cytotoxic agents of BGC-823 cells.
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