A facile and versatile methodology for cysteine specific labeling of proteins with octahedral polypyridyl d6 metal complexes
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- 作者：Sudharsan Dwaraknath ; Ngoc-Han Tran ; Thanh Dao ; Alexander Colbert ; Sarah Mullen ; Angelina Nguyen ; Alejandro Cortez ; Lionel Cheruzel ; lionel.cheruzel@sjsu.edu" class="auth_mail
- 关键词：Biomolecule labeling ; Sulfhydryl specific ; Polypyridyl d6 metal complexes ; 5 ; 6-Epoxy-5 ; 6-dihydro-[1 ; 10]phenanthroline
- 刊名：Journal of Inorganic Biochemistry
- 出版年：July 2014
- 年：2014
- 卷：136
- 期：Complete
- 页码：154-160
- 全文大小：821 K
文摘
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Octahedral d6 metal complexes bearing 5,6-epoxy-5,6-dihydro-[1,10]phenanthroline
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Selective nucleophilic epoxy-ring opening by surface-exposed cysteine residues
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Base-assisted dehydration of protein-bound label compounds promoting aromatization