Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil.
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- 作者：Cristiene Costa Carneiroa ; profacristiene@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Suzana da Costa Santosb ; Ruy de Souza Lino Jr.c ; Maria Teresa Freitas Barad ; Beatriz Abdallah Chaibubd ; Paulo Roberto de Melo Reise ; Dwight Assis Chavese ; Antô ; nio Jorge Ribeiro da Silvaf ; Luana Santos Silvaa ; Daniela de Melo e Silvaa ; Lee Chen-Chena
- 关键词：Punicalagin ; Antigenotoxicity ; Anticytotoxicity ; Chemoprevention ; DNA repair ; Angiogenesis
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：310
- 期：Complete
- 页码：1-8
- 全文大小：1128 K
文摘
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The ellagitannin punicalagin was isolated for the first time from L. pacari leaves.
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The genotoxic and chemopreventive effects of punicalagin were evaluated in mice.
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The highest dose of punicalagin showed significant cytotoxic effect.
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Punicalagin exhibited antigenotoxic effects by the co-, pre- and post-treatment.
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Punicalagin showed angiogenic activity and could be applied for tissue repairing.