New insights into CD4+ T cell abnormalities in systemic sclerosis
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- 作者：Mengguo Liua ; bAuthor Vitae ; Wenyu Wua ; Xinfen Suna ; Ji Yangb ; Jinhua Xua ; Wenwen Fua ; fuww@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author ; Ming Lib ; li.ming@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACA ; anti-centromere antibodies ; ACR ; American College of Rheumatology ; ANA ; anti-nuclear antibodies ; ARA ; anti-RNA polymerase III antibodies ; CCL-20 ; chemokine (C&ndash ; C motif) ligand 20 ; CXCR-4 ; chemokine (C-X-C motif) receptor 4 ; dcSSc ; diffuse cutaneous subset ; DVSMCs ; dermal vascular smooth muscle cells ; ET-1 ; endothelin-1 ; EULAR ; European League Against Rheumatism ; ICAM-1 ; intercellular adhesion molecule 1 ; ICOS ; inducible costimulator ; IL-17 ; interleukin-17 ; lcSSc ; limited cutaneous subs
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：28
- 期：Complete
- 页码：31-36
- 全文大小：743 K
文摘
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We systematically summarize recent data on various CD4+ T cells activation in systemic sclerosis (SSc), and discuss their potential role in promoting inflammaton and fibrosis.
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The T helper cell 17 (Th17)/regulatory T cell (Treg) paradigm is one of the hallmarks of SSc, as Th17-type cytokines can both arouse inflammation and fibrosis. Furthermore, several studies have reported new T cell subsets in the peripheral blood, serum and skin lesions of SSc individuals, including Th9, Th22 cells and their iconic cytokines.
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Moreover, we speculate that the newly-discovered T follicular helper (Tfh) cells may be also involved in the pathogenesis of SSc.