B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas
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- 作者：Nesrine I. Affara1 ; 10 ; Brian Ruffell1 ; 5 ; 8 ; 10 ; Terry R. Medler5 ; Andrew J. Gunderson5 ; Magnus Johansson1 ; Sophia Bornstein7 ; Emily Bergsland2 ; 4 ; Martin Steinhoff3 ; Yijin Li9 ; Qian Gong9 ; Yan Ma9 ; Jane F. Wiesen1 ; 5 ; Melissa H. Wong5 ; 6 ; 8 ; Molly Kulesz-Martin5 ; 6 ; 8 ; Bryan Irving9 ; 11 ; Lisa M. Coussens1 ; 4 ; 5 ; 8 ; coussenl@ohsu.edu" class="auth_mail
- 刊名：Cancer Cell
- 出版年：16 June 2014
- 年：2014
- 卷：25
- 期：6
- 页码：809-821
- 全文大小：4467 K
文摘
Human SCCs associated with high-risk HPV are infiltrated by Ig-producing B cells
B cell depletion or Fc纬R signaling inhibition impedes SCC neoplastic progression
Therapeutic B cell depletion enhances response of established SCCs to chemotherapy
B cell depletion reprograms macrophages to recruit CD8+ T cells to SCCs via CCR5