NH125 reduces the level of CPEB3, an RNA binding protein, to promote synaptic GluA2 expression
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- 作者：Crhistian L. Bender1 ; Qian Yang1 ; Lu Sun1 ; Siqiong June Liu ; sliu@lsuhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CPEB3 ; eEF2 ; NH125 ; AMPA receptors ; GluA2 ; Protein synthesis ; Cerebellum ; Interneurons ; eEF2 kinase
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：531-537
- 全文大小：1730 K
文摘
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NH125, a commonly used inhibitor of eEF2 kinase, increases protein synthesis.
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10 μM NH125 reduces the levels of CPEB3 and increases GluA2 expression.
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NH125 at a low concentration fails to alter the expression of CPEB3 and synaptic GluA2.
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A selective eEF2 kinase inhibitor, A-484954, reduces peEF2, but not CPEB3 levels.
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NH125 has effects that are independent of its ability to inhibit non-eEF2 kinase.