We discover and identify CPSF4 as a novel hTERT promoter-regulating factor in lung cancer cells.
CPSF4 upregulates hTERT promoter activity, hTERT expression and telomerase activity.
Knockdown of CPSF4 inhibits lung cancer growth by downregulating hTERT expression and activity.
CPSF4 and hTERT are highly expressed in lung cancer cells and adenocarcinoma tumor tissues.
CPSF4 and hTERT overexpression is associated with poor progonsis in lung adenocarcinoma patient.