Polymeric drug delivery micelle-like nanocarriers for pulmonary administration of beclomethasone dipropionate

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• 作者：D. Triolo ; E.F. Craparo ; B. Porsio ; C. Fiorica ; G. Giammona ; G. Cavallaro ; ^{gennara.cavallaro@unipa.it}
• 关键词：Polyaspartamide ; Lipoic acid ; Polymeric micelles ; Cell uptake ; Sustained release ; Mucin permeation
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：206-214
• 全文大小：903 K
• 卷排序：151

文摘

Beclomethasone dipropionate (BDP)-loaded PHEA-PEG2000-EDA-LA micelles were realised. These micelles show proper chemical-physical characteristics for lung administration. These micelles were able to permeate through the mucus layer into the lungs. In vitro experiments demonstrate that these micelles result highly biocompatible. These micelles increase drug uptake on 16-HBE compared to Clenil®.