LUMAN/CREB3 is a key regulator of glucocorticoid-mediated stress responses

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• 作者：Jenna Penney^a ; Ari Mendell^b ; Minghua Zeng^a ; Khoa Tran^b ; Jennifer Lymer^c ; Patricia V Turner^d ; Elena Choleris^c ; Neil MacLusky^b ; Ray Lu^a ; ^{rlu@uoguelph.ca}
• 关键词：Glucocorticoid receptor ; LUMAN/CREB3 ; Hypothalamic pituitary adrenal axis ; Stress ; Hippocampus
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：95-104
• 全文大小：2280 K
• 卷排序：439

文摘

Luman-deficient mice exhibit a blunted stress response. Luman deficiency results in increased glucocorticoid receptor (GR) activity. Lower corticosterone levels were observed in Luman-deficient mice. With elevated GR, dendritic branching is reduced in the hippocampal CA3 region. LUMAN is a key regulator of GR-mediated signaling and modulates HPA axis reactivity.