Evaluation of the pharmacological properties of salicylic acid-derivative organoselenium: 2-Hydroxy-5-selenocyanatobenzoic acid as an anti-inflammatory and antinociceptive compound
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- 作者：Pietro Maria Chagas ; Suzan Gon莽alves Rosa ; Marcel Henrique Marcondes Sari ; Carla Elena Sartori Oliveira ; R么mulo Faria Santos Canto ; S么nia Cristina Almeida da Luz ; Antonio Luiz Braga ; Cristina Wayne Nogueira
- 关键词：Salicylate ; Selenium ; Mice ; Nociception ; Inflammation ; Toxicity
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：March, 2014
- 年：2014
- 卷：118
- 期：Complete
- 页码：87-95
- 全文大小：1526 K
文摘
The present study evaluated the antinociceptive and anti-inflammatory effects of per oral (p.o.) administration of salicylic acid-derivative organoselenium compounds in chemical models of nociception in mice. The compounds (50 mg/kg; p.o.) were administered 30 and 60 min before the nociceptive behavior and compared to the positive-control, acetylsalicylic acid (ASA; 200 mg/kg; p.o.). In addition, a dose-response curve (25-100 mg/kg) for compounds was carried out in the formalin test. When assessed in the chemical models, acetic acid-induced writhing behavior, formalin and glutamate tests, the compounds showed the following antinociceptive profile 1B > 2B > 1A > 2A, suggesting a chemical structure-dependent relationship. Then, the anti-inflammatory properties and toxicological potential of compound 1B were investigated. Compound 1B, similar to the positive-control, ASA, diminished the edema formation and decreased the myeloperoxidase activity induced by croton oil (2.5%) in the ear tissue. The results also indicate that a single oral administration of 1B caused neither signs of acute toxicity nor those of gastrointestinal injury. The administration of 1B did not alter the water and food intakes, plasma alanine and aspartate aminotransferase activities or urea levels and cerebral or hepatic 未-aminolevulinate dehydratase activity. Salicylic acid-derivative organoseleniums, mainly compound 1B, have been found to be novel compounds with antinociceptive/anti-inflammatory properties; nevertheless, more studies are required to examine their therapeutic potential for pain treatment.