Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?
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- 作者：Isabelle Lamsoula ; b ; Sandrine Uttenweiler-Josepha ; b ; Christel Moog-Lutza ; b ; Pierre G. Lutza ; b ; Pierre.Lutz@ipbs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：E3 ubiquitin ligase ; Cullin RING ligase ; Ubiquitin-proteasome system ; Therapeutic targets
- 刊名：Biochimie
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：339-347
- 全文大小：1212 K
文摘
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CRLs are key players of the ubiquitylation pathway.
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CRL activity is highly regulated.
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CRL5s targeted specific protein substrates to degradation by the proteasome.
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CRLs that belong to the largest family of E3s represent promising drug targets.
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