Novel cruzipain inhibitors for the chemotherapy of chronic Chagas disease
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- 作者：Marí ; a L. Sbaraglinia ; mlsbaraglini@biol.unlp.edu.ar" class="auth_mail" title="E-mail the corresponding author ; mariasbara@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Carolina L. Belleraa ; Laura Fraccarolib ; Luciana Laroccab ; Carolina Carrillob ; Alan Talevia ; 1 ; Catalina D. Alba Sotoc ; 1
- 关键词：Chagas disease ; Trypanosoma cruzi ; Chronic phase ; Drug repositioning ; Benidipine ; Clofazimine
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：48
- 期：1
- 页码：91-95
- 全文大小：682 K
文摘
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Study of two repurposed drug candidates (benidipine and clofazimine) in a murine model of chronic Chagas disease.
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Benidipine and clofazimine reduce parasite burden in cardiac and skeletal muscle of chronically infected mice.
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These compounds diminished the inflammatory process in cardiac and skeletal muscles.