Combination of retinoid and histone deacetylase inhibitor produced an anti-tumor effect in cutaneous T-cell lymphoma by restoring tumor suppressor gene, retinoic acid receptorβ2, via histone acetylation
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- 作者：Yukihiko Katoa ; b ; 1 ; y-kato@tokyo-med.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Chizu Egusaa ; Tatsuo Maedaa ; Ryoji Tsuboia
- 关键词：RAR ; retinoic acid receptor ; CTCL ; cutaneous T cell lymphoma ; HDAC ; histone deacetylase ; RXR ; retinoid X receptors
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：81
- 期：1
- 页码：17-25
- 全文大小：1611 K
文摘
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Tumor suppressor gene, retinoic acid receptor β2 (RARβ2), was suppressed in CTCL.
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The combination of retinoid with histone acetylation agent restored RARβ2 in CTCL.
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The combination treatment inhibited cell growth by apoptosis in vitro.
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The combination treatment suppressed tumor growth and prolonged survival in vivo.
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This is first report of histone acetylation as primary in restoration of RARβ2.