Transient exposure to proteins SOX2, Oct-4, and NANOG immortalizes exhausted tumor-infiltrating CTLs
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- 作者：Anjuli Bhadurihaucka ; Lei Lia ; Qianqian Lib ; Jianjun Wangb ; Zhengguo Xiaoa ; xiao0028@umd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACT ; TILs ; TICTLs ; STICTLs ; SON ; Nuclear delivery
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：1255-1260
- 全文大小：1374 K
文摘
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TICTLs are sensitive to reprogramming by proteins of stem cell transcription factors, but effector CTLs were not.
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TICTLs are regressed back to an early double negative T cell stage.
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TCR signaling is deregulated by these transcription factors.