Increased levels of inflammatory mediators and proinflammatory monocytes in patients with type I diabetes mellitus and nephropathy

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• 作者：Ingrid Benedicte Moss Kolseth^a ; ^{ingridbenedicte@gmail.com} ; Trine Marita Reine^a ; Krystina Parker^b ; Amanda Sudworth^c ; Bartlomiej J. Witczak^b ; ^d ; Trond Geir Jenssen^e ; ^f ; Svein Olav Kolset^a
• 关键词：Type 1 diabetes mellitus ; Inflammation ; Endothelial dysfunction ; Nephropathy ; Monocyte
• 刊名：Journal of Diabetes and its Complications
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：245-252
• 全文大小：844 K
• 卷排序：31

文摘

To investigate and describe the relationship between diabetic nephropathy and systemic inflammation in patients with type 1 diabetes mellitus (T1DM).MethodsPatients with T1DM, with or without reduced renal function due to diabetic nephropathy, were included. Differences in inflammatory mediators, adhesion molecules, markers of endothelial dysfunction and subsets of monocytes were studied in patients with mean disease duration of 31 years.ResultsPatients with T1DM with and without renal failure were compared. Patients with nephropathy had increased plasma levels of proinflammatory monocytes, as well as circulatory PAI-1, syndecan-1, VEGF, IL-1β, IL-1Ra and CCL4. Peripheral blood mononuclear cells from patients with nephropathy numerically increased soluble ICAM and PAI-1 in co-culture with primary endothelial cells compared to cells from patients without nephropathy.ConclusionsT1DM patients with kidney failure have higher levels of proinflammatory monocytes and circulatory inflammatory mediators compared to patients with T1DM alone. The results highlight the importance of inflammation and endothelial dysfunction in diabetic nephropathy with reduced GFR.