The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells
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- 作者：Xun Jin1 ; 2 ; 5 ; 6 ; 7 ; Hye-Min Jeon1 ; 7 ; Xiong Jin1 ; Eun-Jung Kim1 ; Jinlong Yin3 ; Hee-Young Jeon1 ; Young-Woo Sohn1 ; Se-Yeong Oh1 ; Jun-Kyum Kim1 ; Sung-Hak Kim1 ; 4 ; Ji-Eun Jung1 ; 3 ; Sungwook Kwak1 ; Kai-Fu Tang5 ; Yunsheng Xu5 ; Jeremy N. Rich2 ; Hyunggee Kim1 ; hg-kim@korea.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CULLIN3 ; DVL2 ; GLI2 ; glioblastoma stem cells ; ID1
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 August 2016
- 年：2016
- 卷：16
- 期：6
- 页码：1629-1641
- 全文大小：4517 K
文摘
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ID1 suppresses CULLIN3, which activates GSC self-renewal via SHH and WNT signaling
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CULLIN3 regulates ubiquitin-mediated degradation of DVL2 and GLI2 proteins
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The combined controls of GLI2 and β-CATENIN effectively suppress GSC properties
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The ID1hi/CULLIN3lo signature correlates with poor prognosis of GBM patients