Preliminary investigation of the yeast-mediated reduction of β-keto amides derived from cyclic amines as potential resolution methodology
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- 作者：Rachel E. Saxon ; Hannes Leisch ; Tomas Hudlicky
- 关键词：Dysphoric Hypomania ; Mixed States ; Bipolar
- 刊名：Tetrahedron: Asymmetry
- 出版年：2008
- 出版时间：3 April 2008
- 年：2008
- 卷：19
- 期：6
- 页码：672-681
- 全文大小：192 K
文摘
2-Methylpiperidine and 2-cyclohexylpiperidine were converted to their respective β-keto amides by treatment with diketene. Several strains of yeast were used to reduce the racemic β-keto amides. The unreacted enantiomers were separated from the β-hydroxy amides, the amides cleaved, and the extent of resolution was determined for the cyclic amines. Detailed experimental and spectral data are provided for all compounds.