Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation

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• 作者：Julie C. Etzler^a ; ¹ ; Mariana Bollo^b ; ¹ ; Deborah Holstein^a ; ¹ ; Janice Jianhong Deng^a ; Viviana Perez^c ; Da-ting Lin^a ; Arlan Richardson^d ; Yidong Bai^a ; James D. Lechleiter^a ; ^{lechleiter@uthscsa.edu}
• 关键词：Mitochondrial permeability transition (MPT) ; Mitochondrial respiratory chain complex ; Chaperone ; Prolyl isomerase ; Metabolic regulation
• 刊名：Archives of Biochemistry and Biophysics
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：613
• 期：Complete
• 页码：61-68
• 全文大小：1297 K
• 卷排序：613

文摘

We propose a new molecular mechanism that regulates mitochondrial metabolism. The mechanism depends on increasing the efficiency of mitochondrial respiration. Cyclophilin D promotes complex III activity and accelerates super-complexes formation.